[HTML][HTML] Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase γ
PH Naccache, S Levasseur, G Lachance… - Journal of Biological …, 2000 - ASBMB
The activation of human polymorphonuclear neutrophil leukocytes (neutrophils) is
associated with an increased synthesis of the highly phosphorylated phosphatidylinositol 3,
4, 5-trisphosphate (PtdIns (3, 4, 5) P 3). The aims of the present investigation were to
determine whether the newly described, G protein-dependent phosphatidylinositol 3-kinase
(PI3K), p110γ, was involved in the responses to chemotactic factors interacting with G
protein-coupled receptors. The presence of p110γ in neutrophils was first established both …
associated with an increased synthesis of the highly phosphorylated phosphatidylinositol 3,
4, 5-trisphosphate (PtdIns (3, 4, 5) P 3). The aims of the present investigation were to
determine whether the newly described, G protein-dependent phosphatidylinositol 3-kinase
(PI3K), p110γ, was involved in the responses to chemotactic factors interacting with G
protein-coupled receptors. The presence of p110γ in neutrophils was first established both …