[HTML][HTML] The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan …
T Christophe, A Karlsson, C Dugave, MJ Rabiet… - Journal of Biological …, 2001 - ASBMB
Neutrophils express the G protein-coupled N-formyl peptide receptor (FPR) and its
homologue FPRL1, whereas monocytes express FPR, FPRL1, and FPRL2, an orphan
receptor sharing 83% amino acid identity with FPRL1. FPRL1 is a promiscuous receptor
activated by serum amyloid A and by different synthetic peptides, including the hexapeptide
Trp-Lys-Tyr-Met-Val-d-Met-NH 2 (WKYMVm). By measuring calcium flux in HL-60 cells
transfected with FPR, FPRL1, or FPRL2, we show that WKYMVm activated all three …
homologue FPRL1, whereas monocytes express FPR, FPRL1, and FPRL2, an orphan
receptor sharing 83% amino acid identity with FPRL1. FPRL1 is a promiscuous receptor
activated by serum amyloid A and by different synthetic peptides, including the hexapeptide
Trp-Lys-Tyr-Met-Val-d-Met-NH 2 (WKYMVm). By measuring calcium flux in HL-60 cells
transfected with FPR, FPRL1, or FPRL2, we show that WKYMVm activated all three …