Antibacterial peptide from H. pylori
K Pütsep, CI Brändén, HG Boman, S Normark - Nature, 1999 - nature.com
K Pütsep, CI Brändén, HG Boman, S Normark
Nature, 1999•nature.comColonization of the human stomach by the bacterium Helicobacter pylori is a predisposing
factor for gastrointestinal illnesses such as gastritis and peptic ulcers. But most infections are
asymptomatic, and it has recently been suggested that H. pylori may actually have beneficial
effects on infected carriers who are heavily exposed to other gastrointestinal pathogens. We
find that H. pylori possesses antibacterial activity to which it is itself resistant. We have traced
this activity to cecropin-like amino-terminal peptides derived from the ribosomal protein L1 …
factor for gastrointestinal illnesses such as gastritis and peptic ulcers. But most infections are
asymptomatic, and it has recently been suggested that H. pylori may actually have beneficial
effects on infected carriers who are heavily exposed to other gastrointestinal pathogens. We
find that H. pylori possesses antibacterial activity to which it is itself resistant. We have traced
this activity to cecropin-like amino-terminal peptides derived from the ribosomal protein L1 …
Abstract
Colonization of the human stomach by the bacterium Helicobacter pylori is a predisposing factor for gastrointestinal illnesses such as gastritis and peptic ulcers. But most infections are asymptomatic, and it has recently been suggested that H. pylori may actually have beneficial effects on infected carriers who are heavily exposed to other gastrointestinal pathogens. We find that H. pylori possesses antibacterial activity to which it is itself resistant. We have traced this activity to cecropin-like amino-terminal peptides derived from the ribosomal protein L1 (RpL1).
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