[HTML][HTML] Separation of Transactivation and AP1 Antagonism Functions of Retinoic Acid Receptor α (∗)
S Nagpal, J Athanikar, RAS Chandraratna - Journal of Biological Chemistry, 1995 - ASBMB
Retinoic acid receptors (RARs) regulate gene expression either by directly binding to the
RAR-responsive elements or by antagonizing the action of c-Jun/c-Fos (AP1). AP1 is
involved in the expression of metalloproteases, cytokines and other factors which play
critical roles in the turnover of extracellular matrix, inflammation and hyperproliferation in
diseases such as psoriasis, rheumatoid arthritis and in tumor metastases. We demonstrate
here that synthetic retinoids inhibit 12-O-tetradecanoylphorbol-14-acetate-induced …
RAR-responsive elements or by antagonizing the action of c-Jun/c-Fos (AP1). AP1 is
involved in the expression of metalloproteases, cytokines and other factors which play
critical roles in the turnover of extracellular matrix, inflammation and hyperproliferation in
diseases such as psoriasis, rheumatoid arthritis and in tumor metastases. We demonstrate
here that synthetic retinoids inhibit 12-O-tetradecanoylphorbol-14-acetate-induced …