Cushing's syndrome
DN Orth - New England Journal of Medicine, 1995 - Mass Medical Soc
DN Orth
New England Journal of Medicine, 1995•Mass Medical SocHarvey W. Cushing's 1932 description1 of the syndrome that results from long-term
exposure to glucocorticoids has not been improved upon, but our understanding of its
pathophysiologic features and our ability to diagnose and treat the disorder have increased
dramatically. Normal Hypothalamic–Pituitary–Adrenal Physiology Corticotropin-releasing
hormone (CRH) 2 is synthesized in the hypothalamus and carried to the anterior pituitary in
portal blood (Figure 1). CRH, whose secretion is regulated by a variety of neurotransmitters …
exposure to glucocorticoids has not been improved upon, but our understanding of its
pathophysiologic features and our ability to diagnose and treat the disorder have increased
dramatically. Normal Hypothalamic–Pituitary–Adrenal Physiology Corticotropin-releasing
hormone (CRH) 2 is synthesized in the hypothalamus and carried to the anterior pituitary in
portal blood (Figure 1). CRH, whose secretion is regulated by a variety of neurotransmitters …
Harvey W. Cushing's 1932 description1 of the syndrome that results from long-term exposure to glucocorticoids has not been improved upon, but our understanding of its pathophysiologic features and our ability to diagnose and treat the disorder have increased dramatically.
Normal Hypothalamic–Pituitary–Adrenal Physiology
Corticotropin-releasing hormone (CRH)2 is synthesized in the hypothalamus and carried to the anterior pituitary in portal blood (Figure 1). CRH, whose secretion is regulated by a variety of neurotransmitters,3 is the most potent regulator of corticotropin secretion. Arginine vasopressin and other hypothalamic agents also stimulate corticotropin secretion.4,5
Corticotropin is synthesized as a large precursor, pro-opiomelanocortin (POMC), which . . .
The New England Journal Of Medicine