Treatment of PL/J mice with the superantigen, staphylococcal enterotoxin B, prevents development of experimental allergic encephalomyelitis
JM Soos, J Schiffenbauer, HM Johnson - Journal of neuroimmunology, 1993 - Elsevier
Experimental allergic encephalomyelitis (EAE), an antigen induced autoimmune disease, is
mediated by Vβ8+ CD4+ T cells in PL/J mice after injection with the autoantigen, myelin
basic protein (MBP). Recently the superantigen, staphylococcal enterotoxin B (SEB), has
been shown to peripherally anergize and delete T cells in a Vβ specific manner. By
treatment of PL/J mice with SEB, we have been able to protect PL/J mice from the
development of EAE. Two-color FACS analysis of the spleens of SEB treated mice showed …
mediated by Vβ8+ CD4+ T cells in PL/J mice after injection with the autoantigen, myelin
basic protein (MBP). Recently the superantigen, staphylococcal enterotoxin B (SEB), has
been shown to peripherally anergize and delete T cells in a Vβ specific manner. By
treatment of PL/J mice with SEB, we have been able to protect PL/J mice from the
development of EAE. Two-color FACS analysis of the spleens of SEB treated mice showed …