Prevention of type 1 diabetes

A Rabinovitch, JS Skyler - Medical Clinics, 1998 - medical.theclinics.com
Type 1 diabetes mellitus results from selective destruction of the insulin-producing p cells in
the pancreatic islets of Langerhans. The current concept is that islet p cells are destroyed by
an autoimmune response mediated by T lymphocytes (T cells) that react specifically to one
or more p cell proteins (autoantigens).'There are several lines of evidence to support the
concept that type 1 diabetes is a T cell-mediated autoimmune disease. First, bone marrow
cells from type 1 diabetic subjects transferred type 1 diabetes into human leukocyte antigen …