The phosphatidylserine receptor: a crucial molecular switch?

PM Henson, DL Bratton, VA Fadok - Nature reviews Molecular cell …, 2001 - nature.com
PM Henson, DL Bratton, VA Fadok
Nature reviews Molecular cell biology, 2001nature.com
The uptake and removal of necrotic or lysed cells involves inflammation and an immune
response, due in part to processes that involve members of the collectin family, surface
calreticulin and CD91. Clearance of apoptotic cells, by contrast, does not induce either
inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch
that determines what the outcome will be?
Abstract
The uptake and removal of necrotic or lysed cells involves inflammation and an immune response, due in part to processes that involve members of the collectin family, surface calreticulin and CD91. Clearance of apoptotic cells, by contrast, does not induce either inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch that determines what the outcome will be?
nature.com