[HTML][HTML] β-Amyloid1–42 binds to α7 nicotinic acetylcholine receptor with high affinity: implications for Alzheimer's disease pathology
HY Wang, DHS Lee, MR D'Andrea, PA Peterson… - Journal of Biological …, 2000 - ASBMB
Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the
loss of cholinergic neurons in the brain. The underlying mechanisms leading to these events
are unclear, but the 42-amino acid β-amyloid peptide (Aβ 1–42) is involved.
Immunohistochemical studies on human sporadic Alzheimer's disease brains demonstrate
that Aβ 1–42 and a neuronal pentameric cation channel, the α7 nicotinic acetylcholine
receptor (α7nAChR), are both present in neuritic plaques and co-localize in individual …
loss of cholinergic neurons in the brain. The underlying mechanisms leading to these events
are unclear, but the 42-amino acid β-amyloid peptide (Aβ 1–42) is involved.
Immunohistochemical studies on human sporadic Alzheimer's disease brains demonstrate
that Aβ 1–42 and a neuronal pentameric cation channel, the α7 nicotinic acetylcholine
receptor (α7nAChR), are both present in neuritic plaques and co-localize in individual …