[HTML][HTML] The Na+-Ca2+ exchanger is essential for embryonic heart development in mice
The cardiac Na+-Ca 2+ exchanger 1 (NCX1) is thought to be the major calcium extrusion
mechanism and to play an important role in the regulation of intracellular calcium in the
heart. The Na+-Ca 2+ exchanger is particularly abundant in the heart, although it is found in
a variety of other tissues. To investigate the role of NCX1, we have generated NCX1-
deficient mice. Mice heterozygous for the NCX1 mutation showed no discernable
phenotype, grew normally, and were fertile; however, no viable homozygote was observed …
mechanism and to play an important role in the regulation of intracellular calcium in the
heart. The Na+-Ca 2+ exchanger is particularly abundant in the heart, although it is found in
a variety of other tissues. To investigate the role of NCX1, we have generated NCX1-
deficient mice. Mice heterozygous for the NCX1 mutation showed no discernable
phenotype, grew normally, and were fertile; however, no viable homozygote was observed …