A genetic dissection of the retinoid signalling pathway in the mouse
M Mark, NB Ghyselinck, O Wendling… - Proceedings of the …, 1999 - cambridge.org
M Mark, NB Ghyselinck, O Wendling, V Dupé, B Mascrez, P Kastner, P Chambon
Proceedings of the Nutrition Society, 1999•cambridge.orgTo determine the functions of retinoic acid receptors RAR and RXR, we have systematically
knocked-out their genes by homologous recombination in the embryonic stem cells and
generated null-mutant mice. This approach has allowed us to perform a genetic dissection of
the retinoic acid signalling pathway.
knocked-out their genes by homologous recombination in the embryonic stem cells and
generated null-mutant mice. This approach has allowed us to perform a genetic dissection of
the retinoic acid signalling pathway.
To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.
Cambridge University Press