[HTML][HTML] A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation
While searching for natural ligands for the peroxisome proliferator-activated receptor (PPAR)
γ, we identified a synthetic compound that binds to this receptor. Bisphenol A diglycidyl ether
(BADGE) is a ligand for PPARγ with aK d (app) of 100 μm. This compound has no apparent
ability to activate the transcriptional activity of PPARγ; however, BADGE can antagonize the
ability of agonist ligands such as rosiglitazone to activate the transcriptional and adipogenic
action of this receptor. BADGE also specifically blocks the ability of natural adipogenic cell …
γ, we identified a synthetic compound that binds to this receptor. Bisphenol A diglycidyl ether
(BADGE) is a ligand for PPARγ with aK d (app) of 100 μm. This compound has no apparent
ability to activate the transcriptional activity of PPARγ; however, BADGE can antagonize the
ability of agonist ligands such as rosiglitazone to activate the transcriptional and adipogenic
action of this receptor. BADGE also specifically blocks the ability of natural adipogenic cell …