Living dangerously: how Helicobacter pylori survives in the human stomach
C Montecucco, R Rappuoli - Nature Reviews Molecular Cell Biology, 2001 - nature.com
Nature Reviews Molecular Cell Biology, 2001•nature.com
Helicobacter pylori was already present in the stomach of primitive humans as they left
Africa and spread through the world. Today, it still chronically infects more than 50% of the
human population, causing, in some cases, severe diseases such as peptic ulcers and
stomach cancer. To succeed in these long-term associations, H. pylori has developed a
unique set of virulence factors, which allow survival in a unique and hostile ecological niche—
the human stomach.
Africa and spread through the world. Today, it still chronically infects more than 50% of the
human population, causing, in some cases, severe diseases such as peptic ulcers and
stomach cancer. To succeed in these long-term associations, H. pylori has developed a
unique set of virulence factors, which allow survival in a unique and hostile ecological niche—
the human stomach.
Abstract
Helicobacter pylori was already present in the stomach of primitive humans as they left Africa and spread through the world. Today, it still chronically infects more than 50% of the human population, causing, in some cases, severe diseases such as peptic ulcers and stomach cancer. To succeed in these long-term associations, H. pylori has developed a unique set of virulence factors, which allow survival in a unique and hostile ecological niche — the human stomach.
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