Three chemokines with potential functions in T lymphocyte‐independent and‐dependent B lymphocyte stimulation

C Schaniel, F Sallusto, C Ruedl… - European journal of …, 1999 - Wiley Online Library
C Schaniel, F Sallusto, C Ruedl, P Sideras, F Melchers, AG Rolink
European journal of immunology, 1999Wiley Online Library
Three clustered mouse chemokine genes, ABCD‐1,‐2 and‐3, are all expressed highly in
dendritic cells and, at various levels, in activated B cells. T cell‐independently activated B
cells express ABCD‐1 and‐2, but not‐3. T cell‐dependently activated B cells express all
three. ABCD‐1 attracts activated CD8+ cytotoxic T cells and CD4+ helper T cells of type 1
and 2. ABCD‐2 preferentially attracts type 2 helper T cells, while ABCD‐3 does not attract T
cells at all. Both ABCD‐1 and ABCD‐2 bind to the same receptor (CCR4). In addition, ABCD …
Abstract
Three clustered mouse chemokine genes, ABCD‐1, ‐2 and ‐3, are all expressed highly in dendritic cells and, at various levels, in activated B cells. T cell‐independently activated B cells express ABCD‐1 and ‐2, but not ‐3. T cell‐dependently activated B cells express all three. ABCD‐1 attracts activated CD8+ cytotoxic T cells and CD4+ helper T cells of type 1 and 2. ABCD‐2 preferentially attracts type 2 helper T cells, while ABCD‐3 does not attract T cells at all. Both ABCD‐1 and ABCD‐2 bind to the same receptor (CCR4). In addition, ABCD‐1 binds to a second, unknown, receptor on a separate T cell population. The three chemokines might guide T cell‐independent as well as ‐dependent responses with two types of CD4+ T cells.
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