[HTML][HTML] Maternal high density lipoproteins affect fetal mass and extra-embryonic fetal tissue sterol metabolism in the mouse
JA McConihay, AM Honkomp, NA Granholm… - Journal of lipid …, 2000 - ASBMB
Previous studies have shown that antibodies to cubulin, a receptor on the yolk sac that binds
high density lipoproteins (HDL) and cobalamin, induce fetal abnormalities. Mice with
markedly low concentrations of plasma HDL-cholesterol (HDL-C) give birth to healthy pups,
however. To establish whether maternal HDL-C has a role in fetal development, sterol
metabolism was studied in the fetus and extra-embryonic fetal tissues in wild-type and
apolipoprotein AI-deficient mice (apoAI−/−). Maternal HDL-C content was markedly greater …
high density lipoproteins (HDL) and cobalamin, induce fetal abnormalities. Mice with
markedly low concentrations of plasma HDL-cholesterol (HDL-C) give birth to healthy pups,
however. To establish whether maternal HDL-C has a role in fetal development, sterol
metabolism was studied in the fetus and extra-embryonic fetal tissues in wild-type and
apolipoprotein AI-deficient mice (apoAI−/−). Maternal HDL-C content was markedly greater …