Cholesterol biosynthesis from lanosterol: molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol …
SH Bae, JN Lee, BU Fitzky, J Seong, YK Paik - Journal of Biological …, 1999 - ASBMB
The cDNA encoding the 471-amino acid rat 7-dehydrocholesterol reductase (DHCR), an
enzyme that has been implicated in both cholesterol biosynthesis and developmental
abnormalities (eg Smith-Lemli-Opitz syndrome) in mammals, has been cloned and
sequenced, and the primary structure of the enzyme has been deduced. The DHCR gene
was mapped to chromosome 8q2. 1 by fluorescence in situ hybridization. Rat DHCR,
calculated molecular mass of 54.15-kDa polypeptide, shares a close amino acid identity with …
enzyme that has been implicated in both cholesterol biosynthesis and developmental
abnormalities (eg Smith-Lemli-Opitz syndrome) in mammals, has been cloned and
sequenced, and the primary structure of the enzyme has been deduced. The DHCR gene
was mapped to chromosome 8q2. 1 by fluorescence in situ hybridization. Rat DHCR,
calculated molecular mass of 54.15-kDa polypeptide, shares a close amino acid identity with …
