Scavenger receptor BI (SR-BI) is known to mediate the selective uptake of high density
lipoprotein (HDL) cholesteryl ester (CE) in liver and steroidogenic tissues. To evaluate the
role of SR-BI in plasma lipoprotein metabolism, we have generated transgenic mice with
liver-specific overexpression of murine SR-BI. On a chow diet SR-BI transgenic (SR-BI Tg)
mice have decreased HDL-CE, apoA-I, and apoA-II levels; plasma triglycerides, low density
lipoprotein (LDL) cholesterol, and very low density lipoprotein (VLDL) and LDL apoB were …