[HTML][HTML] Tissue inhibitor of metalloproteinases-3 inhibits shedding of L-selectin from leukocytes
G Borland, G Murphy, A Ager - Journal of Biological Chemistry, 1999 - ASBMB
Although the enzyme or enzymes mediating shedding of L-selectin have not yet been
identified, this activity can be blocked by synthetic hydroxamic acid-based inhibitors of
metalloproteinases such as Ro 31-9790. However, the endogenous matrix
metalloproteinase inhibitor tissue inhibitor of metalloproteinases (TIMP)-1 does not block L-
selectin shedding. Here, we report that TIMP-3, but not TIMP-2, inhibits L-selectin shedding
from mouse and human lymphocytes, Jurkat T cells, and human monocytes. TIMP-3 has an …
identified, this activity can be blocked by synthetic hydroxamic acid-based inhibitors of
metalloproteinases such as Ro 31-9790. However, the endogenous matrix
metalloproteinase inhibitor tissue inhibitor of metalloproteinases (TIMP)-1 does not block L-
selectin shedding. Here, we report that TIMP-3, but not TIMP-2, inhibits L-selectin shedding
from mouse and human lymphocytes, Jurkat T cells, and human monocytes. TIMP-3 has an …