[HTML][HTML] The Gene Structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Its Inhibitory Activities Define the Distinct TIMP Gene Family∗
SS Apte, BR Olsen, G Murphy - Journal of Biological Chemistry, 1995 - ASBMB
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a
critical role in extracellular matrix homeostasis. We have previously cloned human and
mouse TIMP-3 cDNAs and mapped their chromosomal loci (Apte, SS, Mattei, MG., and
Olsen, BR (1994) Genomics 19, 86-90; Apte, SS, Hayashi, K., Seldin, MF, Mattei, MG.,
Hayashi, M., and Olsen, BR (1994) Dev. Dynam. 200, 177-197); the identification of TIMP3
mutations in Sorsby's fundus dystrophy has underscored the functional importance of TIMP …
critical role in extracellular matrix homeostasis. We have previously cloned human and
mouse TIMP-3 cDNAs and mapped their chromosomal loci (Apte, SS, Mattei, MG., and
Olsen, BR (1994) Genomics 19, 86-90; Apte, SS, Hayashi, K., Seldin, MF, Mattei, MG.,
Hayashi, M., and Olsen, BR (1994) Dev. Dynam. 200, 177-197); the identification of TIMP3
mutations in Sorsby's fundus dystrophy has underscored the functional importance of TIMP …