Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

KJ Leco, R Khokha, N Pavloff, SP Hawkes… - Journal of Biological …, 1994 - ASBMB
We have isolated cDNA clones corresponding to a novel mouse metalloproteinase inhibitor.
Five overlapping cDNA clones contain most of the information for a prominent 4.5-kilobase
transcript that was detected in RNA from mouse fibroblasts and adult tissues. Sequence
analysis revealed an open reading frame (ORF) for a protein of 212 amino acids that is 80%
identical to chicken inhibitor of metalloproteinases-3 (ChIMP-3). The 3'-untranslated
sequence also showed remarkable conservation with the chicken gene. The ORF directed …