Characterization of a transformation-sensitive protein in the extracellular matrix of chicken embryo fibroblasts.
J Blenis, SP Hawkes - Journal of Biological Chemistry, 1984 - ASBMB
The extracellular matrix of cultured chicken embryo fibroblasts undergoes a number of
modifications during the early stages of oncogenic transformation. One alteration is
increased production of a small protein (Mr approximately 21,000) which is transiently
deposited in the matrix by transforming cells infected with LA24, a temperature-sensitive
mutant of Rous sarcoma virus (RSV)(Blenis, J., and Hawkes, SP (1983) Proc. Natl. Acad.
Sci. USA 80, 770-774). This protein is a major component of substratum-associated material …
modifications during the early stages of oncogenic transformation. One alteration is
increased production of a small protein (Mr approximately 21,000) which is transiently
deposited in the matrix by transforming cells infected with LA24, a temperature-sensitive
mutant of Rous sarcoma virus (RSV)(Blenis, J., and Hawkes, SP (1983) Proc. Natl. Acad.
Sci. USA 80, 770-774). This protein is a major component of substratum-associated material …