[HTML][HTML] Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics
Y Ueda, E Gong, L Royer, PN Cooper… - Journal of Biological …, 2000 - ASBMB
Both in vitro and in vivostudies of scavenger receptor class B type I (SR-BI) have implicated
it as a likely participant in the metabolism of HDL cholesterol. To investigate the effect of SR-
BI on atherogenesis, we examined two lines of SR-BI transgenic mice with high (10-fold
increases) and low (2-fold increases) SR-BI expression in an inbred mouse background
hemizygous for a human apolipoprotein (apo) B transgene. Unlike non-HDL cholesterol
levels that minimally differed in the various groups of animals, HDL cholesterol levels were …
it as a likely participant in the metabolism of HDL cholesterol. To investigate the effect of SR-
BI on atherogenesis, we examined two lines of SR-BI transgenic mice with high (10-fold
increases) and low (2-fold increases) SR-BI expression in an inbred mouse background
hemizygous for a human apolipoprotein (apo) B transgene. Unlike non-HDL cholesterol
levels that minimally differed in the various groups of animals, HDL cholesterol levels were …