[HTML][HTML] Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells
W Witt, I Kolleck, H Fechner, P Sinha, B Rüstow - Journal of Lipid Research, 2000 - ASBMB
The scavenger receptor class B type I (SR-BI) mediates the selective uptake of cholesterol
and cholesteryl ester (CE) from high density lipoprotein (HDL) into cells. The high
expression in liver and steroidogenic tissues is compatible with a role of SR-BI in reverse
cholesterol transport and steroid hormone synthesis. Ways of regulation thus far described
include induction by trophic hormones via cAMP-activated protein kinase A (PKA) and the
effects of cellular and plasma cholesterol. Here we show that vitamin E (vitE) has a major …
and cholesteryl ester (CE) from high density lipoprotein (HDL) into cells. The high
expression in liver and steroidogenic tissues is compatible with a role of SR-BI in reverse
cholesterol transport and steroid hormone synthesis. Ways of regulation thus far described
include induction by trophic hormones via cAMP-activated protein kinase A (PKA) and the
effects of cellular and plasma cholesterol. Here we show that vitamin E (vitE) has a major …