[HTML][HTML] The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties
JG Neels, BMM van den Berg, A Lookene… - Journal of Biological …, 1999 - ASBMB
The low density lipoprotein receptor-related protein (LRP) is a multifunctional endocytic cell-
surface receptor that binds and internalizes a diverse array of ligands. The receptor contains
four putative ligand-binding domains, generally referred to as clusters I, II, III, and IV. In this
study, soluble recombinant receptor fragments, representing each of the four individual
clusters, were used to map the binding sites of a set of structurally and functionally distinct
ligands. Using surface plasmon resonance, we studied the binding of these fragments to …
surface receptor that binds and internalizes a diverse array of ligands. The receptor contains
four putative ligand-binding domains, generally referred to as clusters I, II, III, and IV. In this
study, soluble recombinant receptor fragments, representing each of the four individual
clusters, were used to map the binding sites of a set of structurally and functionally distinct
ligands. Using surface plasmon resonance, we studied the binding of these fragments to …