Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation
M Johnsen, LR Lund, J Rømer, K Almholt… - Current opinion in cell …, 1998 - Elsevier
M Johnsen, LR Lund, J Rømer, K Almholt, K Danø
Current opinion in cell biology, 1998•ElsevierAnalysis of extracellular matrix degradation systems has led to the insight that in cancer
invasion there is often crucial interplay between cancer cells and several types of
surrounding non-neoplastic stromal cells. Likewise, in normal tissue remodeling processes,
the synthesis of proteolytic components is often distributed between several cell types, and
there are strong similarities between neoplastic and non-neoplastic processes in the same
tissue. Thus, tissue remodeling events are excellent models for studies of extracellular …
invasion there is often crucial interplay between cancer cells and several types of
surrounding non-neoplastic stromal cells. Likewise, in normal tissue remodeling processes,
the synthesis of proteolytic components is often distributed between several cell types, and
there are strong similarities between neoplastic and non-neoplastic processes in the same
tissue. Thus, tissue remodeling events are excellent models for studies of extracellular …
Analysis of extracellular matrix degradation systems has led to the insight that in cancer invasion there is often crucial interplay between cancer cells and several types of surrounding non-neoplastic stromal cells. Likewise, in normal tissue remodeling processes, the synthesis of proteolytic components is often distributed between several cell types, and there are strong similarities between neoplastic and non-neoplastic processes in the same tissue. Thus, tissue remodeling events are excellent models for studies of extracellular proteolysis in cancer. This has become even clearer by recent analyses of genetically modified mice.
Elsevier