[HTML][HTML] Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
M Amano, M Ito, K Kimura, Y Fukata, K Chihara… - Journal of Biological …, 1996 - ASBMB
The small GTPase Rho is implicated in physiological functions associated with actin-myosin
filaments such as cytokinesis, cell motility, and smooth muscle contraction. We have recently
identified and molecularly cloned Rho-associated serine/threonine kinase (Rho-kinase),
which is activated by GTP· Rho (Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Nakafuku,
M., Ito, M., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K.(1996) EMBO J. 15, 2208-
2216). Here we found that Rho-kinase stoichiometrically phosphorylated myosin light chain …
filaments such as cytokinesis, cell motility, and smooth muscle contraction. We have recently
identified and molecularly cloned Rho-associated serine/threonine kinase (Rho-kinase),
which is activated by GTP· Rho (Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Nakafuku,
M., Ito, M., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K.(1996) EMBO J. 15, 2208-
2216). Here we found that Rho-kinase stoichiometrically phosphorylated myosin light chain …