[HTML][HTML] Sphingosine-1-phosphate: signaling inside and out

S Spiegel, S Milstien - FEBS letters, 2000 - Elsevier
S Spiegel, S Milstien
FEBS letters, 2000Elsevier
Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular
second messenger regulating calcium mobilization, and cell growth and survival. Moreover,
the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP,
and consequent regulation of opposing signaling pathways, is an important factor that
determines whether a cell survives or dies. SPP has recently also been shown to be the
ligand for the EDG-1 family of G-protein-coupled receptors, which now includes EDG-1,-3,-5 …
Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathways, is an important factor that determines whether a cell survives or dies. SPP has recently also been shown to be the ligand for the EDG-1 family of G-protein-coupled receptors, which now includes EDG-1, -3, -5, -6 and -8. SPP is thus a lipid mediator that has novel dual actions signaling inside and outside of the cell.
Elsevier