Vasoactive agonists prevent erythrocyte extravasation in thrombocytopenic hamsters
D Shepro, SL Welles, HB Hechtman - Thrombosis research, 1984 - Elsevier
The mediating action of selected vasoactive amines and their respective antagonists on
vascular fragility, visible as cutaneous petechiae, was assayed with thrombocytopenic (TCP)
hamsters. Serotonin (5-HT), norepinephrine (NE), epinephrine, dopamine and isoproterenol
administered IP reduced petechiae significantly within 10 min; phenylephrine had no effect.
Of the natural amines, 5-HT and NE were most effective in reducing petechial sensitivity to
values obtained with untreated, normal animals; hence these two amines only were tested …
vascular fragility, visible as cutaneous petechiae, was assayed with thrombocytopenic (TCP)
hamsters. Serotonin (5-HT), norepinephrine (NE), epinephrine, dopamine and isoproterenol
administered IP reduced petechiae significantly within 10 min; phenylephrine had no effect.
Of the natural amines, 5-HT and NE were most effective in reducing petechial sensitivity to
values obtained with untreated, normal animals; hence these two amines only were tested …