[HTML][HTML] Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway
J Li, K DeFea, RA Roth - Journal of Biological Chemistry, 1999 - ASBMB
Serine/threonine phosphorylation of insulin receptor substrate 1 (IRS-1) has been implicated
as a negative regulator of insulin signaling. Prior studies have indicated that this negative
regulation by protein kinase C involves the mitogen-activated protein kinase and
phosphorylation of serine 612 in IRS-1. In the present studies, the negative regulation by
platelet-derived growth factor (PDGF) was compared with that induced by endothelin-1, an
activator of protein kinase C. In contrast to endothelin-1, the inhibitory effects of PDGF did …
as a negative regulator of insulin signaling. Prior studies have indicated that this negative
regulation by protein kinase C involves the mitogen-activated protein kinase and
phosphorylation of serine 612 in IRS-1. In the present studies, the negative regulation by
platelet-derived growth factor (PDGF) was compared with that induced by endothelin-1, an
activator of protein kinase C. In contrast to endothelin-1, the inhibitory effects of PDGF did …