[HTML][HTML] Post-transcriptional control of cyclooxygenase-2 gene expression: the role of the 3′-untranslated region
The cyclooxygenase (COX)-2 enzyme is responsible for increased prostaglandin formation
in inflammatory states and is the major target of nonsteroidal anti-inflammatory drugs.
Normally COX-2 expression is tightly regulated, however, constitutive overexpression plays
a key role in colon carcinogenesis. To understand the mechanisms controlling COX-2
expression, we examined the ability of the 3′-untranslated region of the COX-2 mRNA to
regulate post-transcriptional events. When fused to a reporter gene, the 3′-untranslated …
in inflammatory states and is the major target of nonsteroidal anti-inflammatory drugs.
Normally COX-2 expression is tightly regulated, however, constitutive overexpression plays
a key role in colon carcinogenesis. To understand the mechanisms controlling COX-2
expression, we examined the ability of the 3′-untranslated region of the COX-2 mRNA to
regulate post-transcriptional events. When fused to a reporter gene, the 3′-untranslated …