The spleen and organized lymph nodes are not essential for the development of gut-induced mucosal immune responses in lymphotoxin-α deficient mice
IA Davis, KA Knight, BT Rouse - Clinical immunology and …, 1998 - Elsevier
Lymphotoxin knock-out (KO) mice generate specific immune responses to orally
administered immunogens despite having neither gut-associated nor peripheral lymphoid
tissues. The spleen, therefore, was expected to play a role in the generation of immune
responses in these KO mice. KO and wild-type (wt) mice were splenectomized and orally
immunized withSalmonella typhimurium. Splenectomy produced the most profound effects
on serum and fecal IgA levels in KO mice. Total and antigen-specific serum and fecal IgA …
administered immunogens despite having neither gut-associated nor peripheral lymphoid
tissues. The spleen, therefore, was expected to play a role in the generation of immune
responses in these KO mice. KO and wild-type (wt) mice were splenectomized and orally
immunized withSalmonella typhimurium. Splenectomy produced the most profound effects
on serum and fecal IgA levels in KO mice. Total and antigen-specific serum and fecal IgA …