Identification of the Hepatocyte Growth Factor Receptor As the c-met Proto-Oncogene Product
DP Bottaro, JS Rubin, DL Faletto, AML Chan… - Science, 1991 - science.org
Science, 1991•science.org
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral
mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid
response to HGF treatment of intact target cells was identified by immunoblot analysis as the
β subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase.
Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that
were recognized by antibodies to c-met directly established the c-met product as the cell …
mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid
response to HGF treatment of intact target cells was identified by immunoblot analysis as the
β subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase.
Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that
were recognized by antibodies to c-met directly established the c-met product as the cell …
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the β subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF.
AAAS