Influence of macrophage depletion on bacterial translocation and rejection in small bowel transplantation
J Fryer, D Grant, J Jiang, P Metrakos, N Ozcay… - …, 1996 - journals.lww.com
J Fryer, D Grant, J Jiang, P Metrakos, N Ozcay, C Ford, B Garcia, R Behme, R Zhong
Transplantation, 1996•journals.lww.comRejection and sepsis can be intimately related following small bowel transplantation when
rejection compromises normal intestinal barrier mechanisms and bacterial translocation
results. Macrophages play a role in controlling the egress of intestinal luminal bacteria-and
they have also been implicated in allograft rejection. In this study, the role of macrophages in
rejection and bacterial translocation was evaluated by depleting macrophages in donors
and/or recipients of rat small bowel allografts with injection of liposome-encapsulated …
rejection compromises normal intestinal barrier mechanisms and bacterial translocation
results. Macrophages play a role in controlling the egress of intestinal luminal bacteria-and
they have also been implicated in allograft rejection. In this study, the role of macrophages in
rejection and bacterial translocation was evaluated by depleting macrophages in donors
and/or recipients of rat small bowel allografts with injection of liposome-encapsulated …
Abstract
Rejection and sepsis can be intimately related following small bowel transplantation when rejection compromises normal intestinal barrier mechanisms and bacterial translocation results. Macrophages play a role in controlling the egress of intestinal luminal bacteria-and they have also been implicated in allograft rejection. In this study, the role of macrophages in rejection and bacterial translocation was evaluated by depleting macrophages in donors and/or recipients of rat small bowel allografts with injection of liposome-encapsulated dichloromethylene diphosphonate (CL 2 MDP).
Lippincott Williams & Wilkins