[HTML][HTML] rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel α1, 4-N-acetylglucosaminyltransferase involved in the …
H Kitagawa, N Egusa, J Tamura… - Journal of Biological …, 2001 - ASBMB
The proteins encoded by the EXT1, EXT2, and EXTL2 genes, members of the hereditary
multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for
the heparan sulfate biosynthesis. Only two homologous genes, rib-1 and rib-2, of the
mammalian EXT genes were identified in theCaenorhabditis elegans genome. Although
heparan sulfate is found in C. elegans, the involvement of the rib-1 and rib-2 proteins in
heparan sulfate biosynthesis remains unclear. In the present study, the substrate specificity …
multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for
the heparan sulfate biosynthesis. Only two homologous genes, rib-1 and rib-2, of the
mammalian EXT genes were identified in theCaenorhabditis elegans genome. Although
heparan sulfate is found in C. elegans, the involvement of the rib-1 and rib-2 proteins in
heparan sulfate biosynthesis remains unclear. In the present study, the substrate specificity …