Studies on four alphaherpesviruses (herpes simplex virus types 1 and 2, pseudorabies virus
and bovine herpesvirus 1) have revealed some common features of their entry into cells.
The pathway of entry can be by fusion of the virion envelope with the cell plasma membrane.
Receptors for binding and entry include heparan sulphate moieties of cell surface
proteoglycans and other as yet unidentified cell surface components. Related glycoproteins
specified by each of the four viruses mediate the binding of virus to heparan sulphate and …