[HTML][HTML] Molecular Mechanism of Thromboxane A2-induced Platelet Aggregation: ESSENTIAL ROLE FOR P2TAC and α2ARECEPTORS
BZS Paul, J Jin, SP Kunapuli - Journal of Biological Chemistry, 1999 - ASBMB
Thromboxane A 2 is a positive feedback lipid mediator produced following platelet
activation. The G q-coupled thromboxane A 2 receptor subtype, TPα, and G i-coupled TPβ
subtype have been shown in human platelets. ADP-induced platelet aggregation requires
concomitant signaling from two P2 receptor subtypes, P2Y1 and P2T AC, coupled to G q and
G i, respectively. We investigated whether the stable thromboxane A 2 mimetic,(15S)-
hydroxy-9, 11-epoxymethanoprosta-5Z, 13E-dienoic acid (U46619), also causes platelet …
activation. The G q-coupled thromboxane A 2 receptor subtype, TPα, and G i-coupled TPβ
subtype have been shown in human platelets. ADP-induced platelet aggregation requires
concomitant signaling from two P2 receptor subtypes, P2Y1 and P2T AC, coupled to G q and
G i, respectively. We investigated whether the stable thromboxane A 2 mimetic,(15S)-
hydroxy-9, 11-epoxymethanoprosta-5Z, 13E-dienoic acid (U46619), also causes platelet …