[HTML][HTML] Isoalloxazine Ring of FAD Is Required for the Formation of the Core in the Hsp60-assisted Folding of Medium Chain Acyl-CoA Dehydrogenase Subunit into …
T Saijo, K Tanaka - Journal of Biological Chemistry, 1995 - ASBMB
We studied the role of FAD in the intramitochondrial folding and assembly of medium-chain
acyl-CoA dehydrogenase (MCAD), a homotetrameric mitochondrial enzyme containing a
molecule of non-covalently bound FAD/monomer. In the MCAD molecule, FAD is buried in a
crevice containing the active center. We have previously shown that upon import into
mitochondria, newly processed MCAD is first incorporated into a high molecular weight
(hMr) complex and that the hMr complex mainly consisted of MCAD-heat-shock protein 60 …
acyl-CoA dehydrogenase (MCAD), a homotetrameric mitochondrial enzyme containing a
molecule of non-covalently bound FAD/monomer. In the MCAD molecule, FAD is buried in a
crevice containing the active center. We have previously shown that upon import into
mitochondria, newly processed MCAD is first incorporated into a high molecular weight
(hMr) complex and that the hMr complex mainly consisted of MCAD-heat-shock protein 60 …