A method for the preparation of 3-ketoacyl-CoA derivatives
C Thorpe - Analytical biochemistry, 1986 - Elsevier
Analytical biochemistry, 1986•Elsevier
A new method for the preparation of 3-ketoacyl-CoA thioesters (from malonylsemialdehyde
to long-chain and phenylpropanoic 3-keto derivatives) is described. It utilizes the facile,
thermodynamically very favorable, hydration of 2-alkynoyl-CoA thioesters by enoyl-CoA
hydratase. The method is simple and avoids laborious organic syntheses or the use of
multicomponent enzymatic methods.
to long-chain and phenylpropanoic 3-keto derivatives) is described. It utilizes the facile,
thermodynamically very favorable, hydration of 2-alkynoyl-CoA thioesters by enoyl-CoA
hydratase. The method is simple and avoids laborious organic syntheses or the use of
multicomponent enzymatic methods.
A new method for the preparation of 3-ketoacyl-CoA thioesters (from malonylsemialdehyde to long-chain and phenylpropanoic 3-keto derivatives) is described. It utilizes the facile, thermodynamically very favorable, hydration of 2-alkynoyl-CoA thioesters by enoyl-CoA hydratase. The method is simple and avoids laborious organic syntheses or the use of multicomponent enzymatic methods.
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