[HTML][HTML] Participation of JAK and STAT Proteins in Growth Hormone-induced Signaling (∗)
The binding of growth hormone leads to dimerization of its receptor, accompanied by
phosphorylation and activation of intracellular tyrosine kinases (JAKs) and the latent
cytoplasmic transcriptions factors STAT1, STAT3, and STAT5. Both JAK1 and JAK2 are
phosphorylated in response to growth hormone in mouse 3T3 F442A and human HT1080
cells. The roles of JAKs in growth hormone signal transduction were examined by using
mutant HT1080 cells missing either JAK1 or JAK2. JAK2 is absolutely required for growth …
phosphorylation and activation of intracellular tyrosine kinases (JAKs) and the latent
cytoplasmic transcriptions factors STAT1, STAT3, and STAT5. Both JAK1 and JAK2 are
phosphorylated in response to growth hormone in mouse 3T3 F442A and human HT1080
cells. The roles of JAKs in growth hormone signal transduction were examined by using
mutant HT1080 cells missing either JAK1 or JAK2. JAK2 is absolutely required for growth …