Antiatherothrombotic properties of statins: implications for cardiovascular event reduction
RS Rosenson, CC Tangney - Jama, 1998 - jamanetwork.com
Clinical trials of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or
statin therapy have demonstrated that baseline or treated low-density lipoprotein (LDL)
cholesterol levels are only weakly associated with net coronary angiographic change or
cardiovascular events. The beneficial effects of statins on clinical events may involve
nonlipid mechanisms that modify endothelial function, inflammatory responses, plaque
stability, and thrombus formation. Experimental animal models suggest that statins may …
statin therapy have demonstrated that baseline or treated low-density lipoprotein (LDL)
cholesterol levels are only weakly associated with net coronary angiographic change or
cardiovascular events. The beneficial effects of statins on clinical events may involve
nonlipid mechanisms that modify endothelial function, inflammatory responses, plaque
stability, and thrombus formation. Experimental animal models suggest that statins may …