Homeostasis of αβ TCR+ T cells
P Marrack, J Bender, D Hildeman, M Jordan… - Nature …, 2000 - nature.com
P Marrack, J Bender, D Hildeman, M Jordan, T Mitchell, M Murakami, A Sakamoto…
Nature immunology, 2000•nature.comCytokines contribute to T cell homeostasis at all stages of T cell existence. However, the
particular cytokine involved varies as T cells progress from a naïve through an activated to a
memory state. In many cases the important cytokines are members of the interleukin 2
subfamily of the short-chain type I cytokines. A case is made for the idea that the
evolutionary divergence of the short-chain family allowed for concurrent divergence in
leukocytes.
particular cytokine involved varies as T cells progress from a naïve through an activated to a
memory state. In many cases the important cytokines are members of the interleukin 2
subfamily of the short-chain type I cytokines. A case is made for the idea that the
evolutionary divergence of the short-chain family allowed for concurrent divergence in
leukocytes.
Abstract
Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type I cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.
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