[HTML][HTML] Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and …
PM Sullivan, H Mezdour, Y Aratani, C Knouff… - Journal of Biological …, 1997 - ASBMB
Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density
lipoprotein receptor, and this interaction is important for maintaining cholesterol and
triglyceride homeostasis. We have used a gene replacement strategy to generate mice that
express the human apoE3 isoform in place of the mouse protein. The levels of apoE mRNA
in various tissues are virtually the same in the human apoE3 homozygous (3/3) mice and
their littermates having the wild type mouse allele (+/+). Total cholesterol and triglyceride …
lipoprotein receptor, and this interaction is important for maintaining cholesterol and
triglyceride homeostasis. We have used a gene replacement strategy to generate mice that
express the human apoE3 isoform in place of the mouse protein. The levels of apoE mRNA
in various tissues are virtually the same in the human apoE3 homozygous (3/3) mice and
their littermates having the wild type mouse allele (+/+). Total cholesterol and triglyceride …