Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine

E Troncy, M Francoeur, I Salazkin, F Yang… - British journal of …, 1997 - Elsevier
E Troncy, M Francoeur, I Salazkin, F Yang, M Charbonneau, G Leclerc, P Vinay, G Blaise
British journal of anaesthesia, 1997Elsevier
We have compared the effects of inhaled nitric oxide (iNO) and iv nitroglycerin (ivGTN) on
the haemodynamic response to phenylephrine-induced hypertension (PEHT) in
anaesthetized pigs. PEHT did not change either pulmonary vascular resistance or gas
exchange throughout all experiments. Both treatments lowered pulmonary arterial pressure
to the same extent (-12.4% iNO;-13.7% ivGTN) and passively via an effect on left atrial
pressure (-26.3% iNO;-31.4% ivGTN). Both treatments failed to reverse the decrease in renal …
We have compared the effects of inhaled nitric oxide (iNO) and i.v. nitroglycerin (ivGTN) on the haemodynamic response to phenylephrine-induced hypertension (PEHT) in anaesthetized pigs. PEHT did not change either pulmonary vascular resistance or gas exchange throughout all experiments. Both treatments lowered pulmonary arterial pressure to the same extent (-12.4% iNO; -13.7% ivGTN) and passively via an effect on left atrial pressure (-26.3% iNO; -31.4% ivGTN). Both treatments failed to reverse the decrease in renal blood flow (RBFc) induced by PEHT, but both increased urinary flow (UF) (+128% iNO; +148% ivGTN). IvGTN significantly increased plasma concentrations of nitrite and nitrate during (+22.7% arterial blood; +26.2% venous blood) and beyond the period of infusion (iNO: +6.4% and +4.9%, respectively). In four control pigs (no PEHT), iNO markedly increased RBFc (+109%), glomerular filtration rate (+72.5%) and UF (+68.7%). We conclude that iNO may have direct cardiac and renal effects, probably via intervention of NO carrier forms such as S-nitroso compounds.
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