[HTML][HTML] Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo
SE Roselaar, A Daugherty - Journal of lipid research, 1998 - ASBMB
Apolipoprotein E (apoE) influences both innate and acquired immunity in cultured cells. To
determine whether apoE affects the immune system in vivo, Listeria monocytogenes (LM)
was administered intraperitoneally (10 4 cfu) to congenic C57BL/6 apoE–/–and+/+ mice (n=
12 in each group). Survival was assessed daily for 5 days. Deficiency of apoE significantly
increased death by day 5 (P= 0.03). The majority of deaths occurred at day 4. Extent of
infection after LM administration was assessed at day 3 by determining colony counts in …
determine whether apoE affects the immune system in vivo, Listeria monocytogenes (LM)
was administered intraperitoneally (10 4 cfu) to congenic C57BL/6 apoE–/–and+/+ mice (n=
12 in each group). Survival was assessed daily for 5 days. Deficiency of apoE significantly
increased death by day 5 (P= 0.03). The majority of deaths occurred at day 4. Extent of
infection after LM administration was assessed at day 3 by determining colony counts in …