Trypanosoma cruzi: IL-10, TNF, IFN-γ, and IL-12 regulate innate and acquired immunity to infection
IA Abrahamsohn, RL Coffman - Experimental parasitology, 1996 - Elsevier
Control of the acute phase ofTrypanosoma cruziinfections is critically dependent on cytokine-
mediated macrophage activation to intracellular killing. We investigated the roles of IL-10,
TNF, IFN-γ, and IL-12 in the control of parasitism by innate and specific immunity. Mice with
disrupted IL-10 genes (IL-10 KO) infected with Y strainT. cruzihave lower parasite numbers
in the blood and tissues and higher IFN-γ and nitric oxide (NO) production by spleen cells
than wild type (WT) mice. Treatment of IL-10 KO and WT mice with recombinant IL-10 …
mediated macrophage activation to intracellular killing. We investigated the roles of IL-10,
TNF, IFN-γ, and IL-12 in the control of parasitism by innate and specific immunity. Mice with
disrupted IL-10 genes (IL-10 KO) infected with Y strainT. cruzihave lower parasite numbers
in the blood and tissues and higher IFN-γ and nitric oxide (NO) production by spleen cells
than wild type (WT) mice. Treatment of IL-10 KO and WT mice with recombinant IL-10 …