[HTML][HTML] Tumor necrosis factor α suppresses the induction of connective tissue growth factor by transforming growth factor-β in normal and scleroderma fibroblasts
DJ Abraham, X Shiwen, CM Black, S Sa, Y Xu… - Journal of Biological …, 2000 - ASBMB
Connective tissue growth factor (CTGF) is overexpressed in a variety of fibrotic disorders,
presumably secondary to the activation and production of transforming growth factor-β (TGF-
β), a key inducer of fibroblast proliferation and matrix synthesis. The CTGF gene promoter
has a TGF-β response element that regulates its expression in fibroblasts but not epithelial
cells or lymphocytes. Recent studies have shown that the macrophage-produced cytokine
tumor necrosis factor α (TNFα) is necessary to promote inflammation and to induce genes …
presumably secondary to the activation and production of transforming growth factor-β (TGF-
β), a key inducer of fibroblast proliferation and matrix synthesis. The CTGF gene promoter
has a TGF-β response element that regulates its expression in fibroblasts but not epithelial
cells or lymphocytes. Recent studies have shown that the macrophage-produced cytokine
tumor necrosis factor α (TNFα) is necessary to promote inflammation and to induce genes …