[HTML][HTML] Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1
RC Chambers, P Leoni, OP Blanc-Brude… - Journal of Biological …, 2000 - ASBMB
The coagulation protease thrombin plays a critical role in hemostasis and exerts pro-
inflammatory and pro-fibrotic effects via proteolytic activation of the major thrombin receptor,
protease-activated receptor-1 (PAR-1). Connective tissue growth factor (CTGF) is a novel
fibroblast mitogen and also promotes extracellular matrix protein production. It is selectively
induced by transforming growth factor β (TGF-β) and is thought to be the autocrine agent
responsible for mediating its pro-fibrotic effects. CTGF is up-regulated during tissue repair …
inflammatory and pro-fibrotic effects via proteolytic activation of the major thrombin receptor,
protease-activated receptor-1 (PAR-1). Connective tissue growth factor (CTGF) is a novel
fibroblast mitogen and also promotes extracellular matrix protein production. It is selectively
induced by transforming growth factor β (TGF-β) and is thought to be the autocrine agent
responsible for mediating its pro-fibrotic effects. CTGF is up-regulated during tissue repair …