Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase–binding protein (E3BP) and the glycine cleavage proteins in primary …
L Dubel, A Tanaka, PS Leung, J Van de Water… - Hepatology, 1999 - journals.lww.com
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the
presence of antimitochondrial antibodies (AMA) directed primarily against the E2 subunits of
the pyruvate dehydrogenase complex, the branched chain 2–oxo–acid dehydrogenase
complex, the 2–oxoglutarate dehydrogenase complex, as well as the dihydrolipoamide
dehydrogenase–binding protein (E3BP) of pyruvate dehydrogenase complex. The
autoantibody response to each E2 subunit is directed to the lipoic acid binding domain …
presence of antimitochondrial antibodies (AMA) directed primarily against the E2 subunits of
the pyruvate dehydrogenase complex, the branched chain 2–oxo–acid dehydrogenase
complex, the 2–oxoglutarate dehydrogenase complex, as well as the dihydrolipoamide
dehydrogenase–binding protein (E3BP) of pyruvate dehydrogenase complex. The
autoantibody response to each E2 subunit is directed to the lipoic acid binding domain …