[HTML][HTML] Identification of Novel DNA Binding Targets and Regulatory Domains of a Murine Tinman Homeodomain Factor, nkx-2.5 (∗)
CY Chen, RJ Schwartz - Journal of Biological Chemistry, 1995 - ASBMB
A murine cardiac-specific homeodomain gene named csx (Komuro, I., and Izumo. S.(1993)
Proc. Natl. Acad. Sci. USA 90, 8145-8149) and nkx-2.5 (Lints, TJ, Parsons, LM, Hartley, L.,
Lyons, I., and Harvey, RP (1993) Development 119, 419-431) was identified as a potential
vertebrate homologue of Drosophila tinman, a mesoderm determination factor required for
insect heart formation (Bodmer, R.(1993) Development 118, 719-729). Bacterial expression
of the nkx-2.5 homeodomain allowed us to identify downstream DNA targets from a library of …
Proc. Natl. Acad. Sci. USA 90, 8145-8149) and nkx-2.5 (Lints, TJ, Parsons, LM, Hartley, L.,
Lyons, I., and Harvey, RP (1993) Development 119, 419-431) was identified as a potential
vertebrate homologue of Drosophila tinman, a mesoderm determination factor required for
insect heart formation (Bodmer, R.(1993) Development 118, 719-729). Bacterial expression
of the nkx-2.5 homeodomain allowed us to identify downstream DNA targets from a library of …