Altering cardiac function via transgenesis a nuts and bolts approach

J Robbins - Trends in cardiovascular medicine, 1997 - Elsevier
Transgenesis provides a means to modify the mammalian genome. By directing expression
of a engineered protein to the heart, one now is able to remodel effectively the cardiac
protein profile and study the consequences of a single genetic manipulation at the
molecular, biochemical, cytological, and physiologic levels. Often, a particular pathology or
even a global remodeling process such as hypertrophy is accompanied by the upregulation
or downregulation of a gene or set (s) of genes. What is not known is whether these changes …